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KMID : 1188320160100050749
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Gut and Liver
2016 Volume.10 No. 5 p.749 ~ p.756
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PMK-S005 Alleviates Age-Related Gastric Acid Secretion, Inflammation, and Oxidative Status in the Rat Stomach
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Choi Yoon-Jeong
Kim Na-Young
Lee Ju-Yup
Nam Ryoung-Hee
Suh Ji-Hyung
Lee Sun-Min
Ham Min-Hee
Jo Hyun-Jin
Shim Young-Kwang
Park Yo-Han
Lee Jong-Chan
Choi Yoon-Jin
Lee Hye-Seung
Lee Dong-Ho
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Abstract
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Background/Aims:The aim of this study was to evaluate the effect of the synthetic S-allyl-l-cysteine (SAC) PMK-S005 on gastric acid secretion, inflammation, and antioxidant enzymes in aging rats.
Methods:The rats were divided into four groups at 31 weeks of age and were continuously fed a diet containing a vehicle control, PMK-S005 (5 or 10 mg/kg), or lansoprazole (5 mg/kg). Gastric acid secretion and connective tissue thickness of the lamina propria were evaluated at 74 weeks and 2 years of age. Tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and COX-2 levels were measured by using enzyme-linked immunosorbent assays (ELISAs) or Western blot assays. Levels of antioxidant enzymes, including heme oxyganase 1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO-1), were also measured.
Results:As the rats aged, gastric acid secretion significantly decreased, and the connective tissue of the lamina propria increased. However, 74-week-old rats in the PMK-S005 group exhibited greater levels of gastric acid secretion than those of the control and lansoprazole groups. The increase of TNF-α, IL-1β, and COX-2 expression in 74-week and 2-year-old control rats were inhibited by PMK-S005. In addition, the decrease in HO-1 and NQO-1 protein expression that occurred with aging was inhibited by PMK-S005 in the 74-week-old rats.
Conclusions:These results suggest that PMK-S005 has therapeutic potential as an antiaging agent to ameliorate age-related gastric acid secretion, inflammation, and oxidative stress in the stomach.
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KEYWORD
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s-allyl--cysteine, Aging, Gastric acid, Anti-inflammation, Antioxidants
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